Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, including gastrointestinal (GI) dysfunction and cognitive decline. Emerging evidence suggest that anti-inflammatory dietary patterns (AIDP) may influence disease progression through the gut-brain axis. This study investigated the effects of a 12-week AIDP intervention on GI symptoms, global functioning, and cognitive functioning in individuals with PD, with a focus on sex differences. An open label randomized controlled trail with cross over design was used to evaluate changes in dietary adherence (DHD-FFQ), GI symptoms (GSRS), global functioning (OQ-45/GAF), and cognitive functioning (BAC). A total of 47 participant were included. Results indicated significant improvements in diet quality in both sexes, demonstrating feasibility of dietary change in PD. Changes in GI symptoms, global functioning, and cognitive functioning were limited. Females outperformed males in verbal memory, motor speed, and executive functioning. However, limited significant interaction was found between sex and intervention, suggesting similar dietary responses across sexes. Stability in symptom scores may still suggest a slowing of disease progression, which is clinically relevant in a neurodegenerative context. The short intervention period, small sample size, and use of non-PD-specific instruments may have limited the detection of clinically meaningful changes. These findings support the integration of AIDPs as a low-risk, feasible component of comprehensive PD management. Future studies should include longer interventions, larger samples, PD-specific outcome measures, and account for variables such as medication use, objective biomarkers and sex, to better assess the potential of dietary strategies to complement existing treatments.