The behavioral immune system predicts that disgust sensitivity is related to decreased sexual risk behavior, but whether this association depends on willingness to engage in uncommited sex is untested. Using an inherited two-wave dataset of University of Amsterdam students (N = 516), this study tested whether disgust sensitivity predicts safer-sex behavior and whether sociosexual orientation moderates that association. Higher disgust sensitivity predicted safer-sex behavior, an effect carried mainly by sexual disgust. Sociosexual orientation did not moderate this association, the two predictors operated additively rather than interactively. Disgust sensitivity relates to safer-sex behavior across sociosexual orientation, though the cross-sectional design precludes causal inference.