Mild traumatic brain injury (mTBI) can lead to symptoms such as cognitive impairment, headaches, mood changes, and vertigo. In ~15% of cases, these symptoms last beyond three months. To move beyond a "one-size-fits-all" approach, a new Dutch guideline recommends a symptom cluster-based approach to treatment. However, existing cluster studies are based on acute-phase or sport populations, limiting their generalizability. This study aimed to identify persistent symptom groups in mTBI patients starting multidisciplinary rehabilitation, and to identify patient groups based on patterns of co-occurring symptoms. Additionally, differences in demographic, clinical, and psychological characteristics across patient subgroups were explored. In this cross-sectional study, 77 patients (Mdn = 12-months post-injury) referred to Heliomare Rehabilitation completed the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Symptom groups were identified using Principal Component Analysis (PCA) on RPQ-scores. For each patient, the contribution of each symptom group to their overall symptom burden was calculated. These profiles underwent k-means clustering to identify patient groups. Additional measures included the Dutch Multifactor Fatigue Scale, Hospital Anxiety and Depression Scale, and Utrecht Scale for Evaluation of Rehabilitation-Participation. PCA identified five symptom groups: cognitive, emotional, vestibular-ocular, light sensitivity-slowed thinking, and headache-noise sensitivity-fatigue. K-means clustering identified patient groups characterised by predominantly high emotional, vestibular-ocular, or cognitive symptoms. These groups differed in symptom severity, mood and anxiety symptoms, fatigue, and participation. These findings partially overlapped with previous studies, indicating that current guidelines are not directly applicable to rehabilitation settings and require further research. Limited by a small sample size, this pilot provides directions for larger-scale research