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Presentation Master's Thesis - Aleta de Ruiter - Brain & Cognition

Laatst gewijzigd op 31-10-2022
Hippocampal subfields at 7T MRI in Parkinson's disease without cognitive impairment
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02-11-2022 12:00
02-11-2022 13:00

Roeterseilandcampus -Building G


Roetersstraat 11 



Little is known about the integrity of the hippocampal subfields in Parkinson’s disease (PD). In this study, we investigated potential volumetric hippocampal subfield alterations in PD patients without cognitive impairment. Additionally, we investigated the possible relationship between hippocampal subfield volume and the severity of non-motor symptoms in PD. For this purpose, we manually delineated left and right hippocampal subfields on 7-Tesla whole-brain structural magnetic resonance imaging (MRI) scans of five PD patients without cognitive impairment and five healthy controls. The severity of non-motor symptoms was measured with the Non-Motor Aspects of Experiences of Daily Living (nM-EDL) subscale, part of the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS- UPDRS). 

The median volume estimates of the groups indicated lower volumes in PD patients for DG/CA4, CA3/2, left subiculum, pre/parasubiculum, and left uncus. Conversely, there were higher volumes in PD patients for CA1, right subiculum, and right uncus. We had specific hypotheses for CA3/2; therefore, the CA3/2 volume was used for the statistical analysis. The main findings can be summarised as follows: i) no significant differences were found in CA3/2 volume between left and right hemispheres within groups, ii) no significant differences were found in average CA3/2 volume between groups, and iii) no correlation was found between average CA3/2 volume and total scores on the nM-EDL. In conclusion, we found no evidence supporting volumetric alterations in the CA3/2 region of PD patients without cognitive impairment. Furthermore, no relationship was identified between CA3/2 volume and the severity of non-motor symptoms. Future studies with larger and matched groups are needed to assess the validity of these findings and determine the clinical utility of CA3/2 volumetry in the progression of PD.