Brain and Cognitive Sciences (Research-Master)

Faculty of Science

ABC Colloquium: Lars Muckli

Centre for Cognitive Neuroimaging, University of Glasgow

27Nov2015 16:00 - 17:00


Predictive coding of auditory and contextual information in early visual cortex – evidence from layer specific fMRI brain reading

Ultra-high field (7T) layer specific brain imaging of top-down internal models

Normal brain function involves the interaction of internal processes with incoming sensory stimuli. 

We have created a series of brain imaging experiments that sample internal models and feedback mechanisms in early visual cortex. Primary visual cortex (V1) is the entry-stage for cortical processing of visual information. We can show that there are two information counter-streams concerned with: 

(1) retinotopic visual input and

(2) top-down predictions of internal models generated by the brain. 

Our results speak to the conceptual framework of predictive coding. Internal models amplify and disamplify incoming information. The brain is a prediction-machinery. Healthy brain function will strike a balance between precision of prediction and prediction update based on prediction error. 

Our results incorporate state of the art, layer-specific ultra-high field fMRI and other imaging techniques.


Diamantbeurs 5.01

Published by  Amsterdam Brain and Cognition (ABC)